My research focuses on explaining and characterizing the dynamics of proteins.  I have analyzed proteins in our Dynameomics database to examine dynamics broadly as well as a smaller set of methyltransferase proteins with common SNPs to examine how changes in structure relate to dynamics.

The motion of proteins is often difficult to interpret.  Using signal processing techniques, it may be possible to elucidate comparable features of protein trajectories.

Using Principal Component Analysis, we can determine a primary direction and magnitude of an atom’s flexibility.  By mining the entire Dynameomics database, we have discovered many interesting things about how proteins move.

Much research has already found applications of rudimentary graph representations of proteins.  By representing similar chemical regions of a protein as nodes in a graph, I hope to simplify the observation of chemical changes over time.

Wavelet analysis of protein motions

Protein Flexibility

Chemical Environment: Protein Graphs

Research

1959 NE Pacific St

Box 357240

Seattle, WA 98195-7240

Phone: 206-616-0369

Fax: 206-221-2671

email: nben@u.washington.edu

NLM Informatic Research Fellow

ARCS Research Fellow

Daggett Lab, University of Washington

Noah Benson