BSTR520 winter 2004

Syllabus

Week	Topic	Resources
1/6/04 Wim Hol	Introduction Principle of drug action	Structure-Based Drug Design Biological principles of Drug Action
1/8/04 Wim Hol	Principle of drug action	Biological principle of Drug Action
1/13/04 Mike Gelb	Transition state based drug design Mechanism state based drug design	No ppt available
1/15/04 David Hyre	Thermodynamics of ligand binding	Thermodynamics: Practical Calorimetry for binding and stability supplementary material
1/20/04 Erkang Fang	Combinatorial Chemistry I Combinatorial Chemistry II	Combinatorial Chemistry for drug design
1/22/04 Wim Hol	Protein stabilizing drugs	Physical chemical principles
1/27/04 Wim Hol	Physical chemical principles I Physical chemical principles II	Physical chemical principles
1/29/04 Christophe Verlinde	Forces and energies
2/3/04 Christophe Verlinde	Molecular Dynamic simulations & Perturbation theory Solvation
2/5/04 Christophe Verlinde	Docking
2/10/04 Christophe Verlinde	Scoring functions I Scoring functions I
2/12/04 Patricia Campbell	SAR by NMR
2/17/04 Christophe Verlinde	Absorption, distribution, metabolism, excretion and toxicity -Part I Absorption, distribution, metabolism, excretion and toxicity -Part II
2/19/04 Wim Hol	HIV protease
2/24/04 Gabriele Varani	RNA Inhibition I RNA Inhibition II
2/26/04 Mike Gelb	PFT inhibitors
3/2/04 Erkang Fang	The power of multivalency  I The power of multivalency  II
3/4/04 Christophe Verlinde	Adenosine pockets
3/9/04 Pradip Rathod Wim Hol	Resistance Malaria Resistance Mechanism I
3/11/04 Wim Hol	Resistance Mechanism II