September 2009

Amanda Jonsson

Biomolecular Structure & Design Program

Department of Biochemistry

University of Washington, Seattle, WA

ajonsson@u.washington.edu

http://students.washington.edu/ajonsson/

 

Education:

            University of Washington

                        Biomolecular Structure & Design Program

                        Department of Biochemistry

                        Seattle, WA 98195

                        Ph.D., Biochemistry (2009)

 

Loyola University Chicago

Chicago, IL 60626

                        B.S. with honors, Chemistry with an emphasis in biology (2003)

 

Professional experience:

            University of Washington, Department of Bioengineering

                        Postdoctoral Fellow (6/09 – present)

Characterization of the unfolding pathways of β-proteins and large-scale simulation and analysis of structurally diverse proteins as part of the Dynameomics project

                        Advisor: Dr. Valerie Daggett

 

University of Washington, Department of Biochemistry

Biochemistry Teaching Assistant (10/04-4/05)

Graduate Student (10/03 –6/09)

      Identification and characterization of the transition state ensemble from unfolding simulations of a diverse set of proteins to help understand the protein folding pathway

Advisor: Dr. Valerie Daggett

 

Loyola University Chicago, Department of Chemistry

Chemistry Teaching Assistant (9/01-6/03)

Undergraduate Research (9/01-6/03)

Characterization of the change in quaternary structure of the subunits of hemoglobin upon oxygen binding

Advisor: Dr. Kenneth W. Olsen

 

University of Cincinnati, Department of Chemistry

Research Experience for Undergraduates (6/02-9/02)

Organic chemistry synthesis to design peptidomimetics

Advisor: Dr. David Smithrud

           

Awards:

            Mulcahy Scholar 2001-2003, Loyola University Chicago

Junior of the Year 2002, Chemistry Department, Loyola University Chicago

            Father Morrissey Medal 2003, Loyola University Chicago

            Molecular Biophysics Training Grant 2004-2007, University of Washington

 

Presentations:

January 2006, Ventura, CA

Protein Folding Gordon Research Graduate School

Jonsson, A. L., Beck, D. A. C., Day, R., Schaeffer, R. D., Scott, K. A., Alonso, D. O. V., and Daggett, V. Dynameomics: Molecular Dynamics Simulations of Fold-Space Representatives, lecture

            January 2006, Ventura, CA

                        Protein Folding Gordon Research Conference

Beck, D. A. C., Day, R., Jonsson, A. L., Schaeffer, R. D., Scott, K. A., Alonso, D. O. V., and Daggett, V. Dynameomics: Molecular Dynamics Simulations of Fold-Space Representatives, poster

            March 2003, New Orleans, LA

                        American Chemical Society Meeting

Jonsson, A. L. and Olsen, K. W. Effect of conformational changes in the individual subunits on the quaternary structure of Hemoglobin, poster

 

Publications:

  1. Petrovich M., Jonson A.L., Ferguson N., Daggett, V., and Fersht A.R. F-Analysis at the experimental limits: mechanism of β-hairpin formation. Journal of Molecular Biology 360: 865-881, 2006.
  2. Sharpe T., Jonsson A.L., Rutherford T.J., Daggett, V., and Fersht A.R. The role of the first turn in β-hairpin formation during WW domain folding. Protein Science 16: 2233-2239, 2007.
  3. Beck D.A.C, Jonsson A.L., Schaeffer R.D., Scott K.A., Day R., Toofanny R.D., Alonso D.O.V., and Daggett, V. Dynameomics: mass annotation of protein dynamics and unfolding in water by high-throughput atomistic molecular dynamics simulations. Protein Engineering Design & Selection 21: 353-368, 2008.
  4. Jonsson A.L., Scott K.A. and Daggett, V. Dynameomics: A consensus view of the protein unfolding/folding transition state ensemble across a diverse set of protein folds. Biophysical Journal. In press. 2009
  5. Toofanny R.D., Jonsson A.L., and Daggett,V. Dynameomics: Methods for high throughput transition state assignment. In preparation.
  6. Van der Kamp M.W., Schaeffer R.D., Jonsson A.L., Scouras A.D., Simms A., Toofanny R.D., Benson N.C., Anderson P.C., Merkley E.D., Rysavy S., Beck D.A.C., and Daggett V. Dynameomics: A database of large-scale simulation and analysis dynamics and unfolding. In preparation.

 

Miscellaneous:

            Seattle Expanding Your Horizons

Organization Committee Member, 10/04 – 9/08

Refreshments Committee Chair, 10/04 – 2/08

Conference to encourage middle school girls to pursue careers in math, science and technology

 

References:

            Available upon request